Publications

2026

Kusi-Appiah G, Schmollinger S, Mamo A, Stainbrook SC, O'Halloran TV, Strenkert D. CIA5 and its interacting metal-binding GTPase ZNG3 are degraded by the proteasome in Zn deficiency. Plant J. 2026 Jul;127(1):e71035. doi: 10.1111/tpj.71035. PMID: 42448334; PMCID: PMC13368412.

Roter B, Crawford AM, O'Halloran TV, Jacobsen C. X-ray fluorescence microscopy exposure estimates using a single excitation energy. J Synchrotron Radiat. 2026 Jul 1;33(Pt 4):1074-1084. doi: 10.1107/S1600577526004923. Epub 2026 Jun 16. PMID: 42301795; PMCID: PMC13344639.

Clark MM, Kashefi K, Reguera G. Cation-driven envelope dynamics modulate outer membrane vesiculation and extracellular electron transfer in Geobacter. Nat Commun. 2026 Jun 22;17(1):7859. doi: 10.1038/s41467-026-74523-w. PMID: 42331822; PMCID: PMC13442872.

Roter B, Crawford AM, Jin Q, Glowacki AT, Lai B, Marin FS, Maxey E, Shi X, Culotta VC, Wildeman AS, Patel NK, O'Halloran TV, Jacobsen C. Multifunctional bending magnet beamline with a capillary optic for X-ray fluorescence studies of metals in tissue sections. J Synchrotron Radiat. 2026 Mar 1;33(Pt 2):319-330. doi: 10.1107/S1600577526000925. Epub 2026 Feb 19. PMID: 41712662; PMCID: PMC12948027.

Zee DZ, Ahn SH, Crawford AM, Sinha N, Jin Q, Jacobsen C, Maxey E, Lai B, MacRenaris KW, O'Halloran TV. Substrate and standard evaluation for correlative elemental mapping of biological samples by X-ray fluorescence microscopy and laser ablation ICP-MS. J Anal At Spectrom. 2026 Jan 16;41(2):708-721. doi: 10.1039/d5ja00371g. PMID: 41551907; PMCID: PMC12809665.

Czerniak CW, Connon ML, Wintersheimer E, Freitas E, MacRenaris KW, Schaffer JE, Griebel AJ, Zhou L, Sahoo D, Guillory RJ 2nd. Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo. Acta Biomater. 2026 Mar;213:791-804. doi: 10.1016/j.actbio.2026.01.028. Epub 2026 Jan 14. PMID: 41544917; PMCID: PMC13183297.

Balough JL, O’Halloran TV, Duncan FE, Woodruff TK. Inorganic profiles of preimplantation embryos reveal a role for zinc in blastocyst development. Reproduction 2026 Jan;171(1); DOI: https://doi.org/10.1093/reprod/xaaf014

2025

Rangarajan AA, Ok K, Malleck MK, Ferrell MJ, O'Halloran TV, Waters CM. A cyclic di-GMP phosphodiesterase in the VSP-2 island of Vibrio cholerae is regulated by zinc and quorum sensing. mBio. 2025 Nov 12;16(11):e0227525. doi: 10.1128/mbio.02275-25. Epub 2025 Sep 24. PMID: 40990477; PMCID: PMC12607878.

Jiang Y, Nikolovski M, Wang T, MacRenaris K, O'Halloran TV, Hu J. Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter. Chem Sci. 2025 Aug 26;16(38):17675-17687. doi: 10.1039/d5sc03700j. PMID: 40910126; PMCID: PMC12406047.

Kim T, Hong B, Northcote R, O'Halloran TV, Lisabeth E, Neubig RR, Fiebig A, Crosson S. Reversion of a RND transporter pseudogene reveals latent stress resistance potential in Brucella ovis. PLoS Genet. 2025 Jul 21;21(7):e1011795. doi: 10.1371/journal.pgen.1011795. PMID: 40690529; PMCID: PMC12306736.

Crawford AM, Zee DZ, Jin Q, Sue A, Sinha N, Ahn SH, O'Halloran TV, MacRenaris KW. AutoSpect: an all-in-one software solution for automated processing of LA-ICP-TOF-MS datasets. J Anal At Spectrom. 2025 Jul 2;40(8):2162-2178. doi: 10.1039/d5ja00145e. PMID: 40657301; PMCID: PMC12243102.

Ahn SH, Halgren K, Grzesiak G, MacRenaris KW, Sue A, Xie H, Demireva E, O'Halloran TV, Petroff MG. Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology. J Immunol. 2025 Jul 1;214(7):1504-1516. doi: 10.1093/jimmun/vkaf054. PMID: 40267393; PMCID: PMC12311386.

Hernandez-Ortiz S, Ok K, O'Halloran TV, Fiebig A, Crosson S. A co-conserved gene pair supports Caulobacter iron homeostasis during chelation stress. J Bacteriol. 2025 Apr 17;207(4):e0048424. doi: 10.1128/jb.00484-24. Epub 2025 Mar 14. PMID: 40084995; PMCID: PMC12004947.

2024

He W, MacRenaris KW, Griebel A, Kwesiga MP, Freitas E, Gillette A, Schaffer J, O'Halloran TV, Guillory II RJ. Semi-quantitative elemental imaging of corrosion products from bioabsorbable Mg vascular implants in vivo. Bioact Mater. 2024 Sep 24;43:225-239. doi: 10.1016/j.bioactmat.2024.07.023. PMID: 39386222; PMCID: PMC11462046.

Iskhakova K, Cwieka H, Meers S, Helmholz H, Davydok A, Storm M, Baltruschat IM, Galli S, Pröfrock D, Will O, Gerle M, Damm T, Sefa S, He W, MacRenaris K, Soujon M, Beckmann F, Moosmann J, O'Hallaran T, Guillory II RJ, Wieland DCF, Zeller-Plumhoff B, Willumeit-Römer R. Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stages. Bioact Mater. 2024 Sep 3;41:657-671. doi: 10.1016/j.bioactmat.2024.07.019. PMID: 39296873; PMCID: PMC11408010.

Halim A, Mondal SK, Al-Qadi N, Kenyon E, MacRenaris K, O'Halloran TV, Medarova Z, Moore A. Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases. J Vis Exp. 2024 Aug 23;(210). doi: 10.3791/66961. PMID: 39248512.

Jiang Y, MacRenaris K, O'Halloran TV, Hu J. Determination of metal ion transport rate of human ZIP4 using stable zinc isotopes. J Biol Chem. 2024 Aug 9:107661. doi: 10.1016/j.jbc.2024.107661. Epub ahead of print. PMID: 39128710.

Pawelec KM, Hix JML, Troia A, MacRenaris KW, Kiupel M, Shapiro EM. In vivo micro-computed tomography evaluation of radiopaque, polymeric device degradation in normal and inflammatory environments. Acta Biomater. 2024 Jun;181:222-234. doi: 10.1016/j.actbio.2024.04.031. Epub 2024 Apr 20. PMID: 38648912; PMCID: PMC11144086.

Broda M, Jakes JE, Li L, Antipova OA, Maxey ER, Jin Q. Conservation of model degraded pine wood with selected organosilicons studied by XFM and nanoindentation. Wood Sci Technol. 2024 Mar;58(2):649-675. doi: 10.1007/s00226-024-01533-6. Epub 2024 Feb 10. PMID: 39990724; PMCID: PMC11845243.

2023

Lee Y, Rong Q, Song KH, Czaplewski DA, Zhang HF, Yao J, Sun C. Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors. Photoacoustics. 2023 Nov 29;34:100574. doi: 10.1016/j.pacs.2023.100574. PMID: 38126078; PMCID: PMC10731384.

Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A, Nejad FK, Mahmoodzadeh A, Sato T, Ramos-Alonso L, Romero AM, Martinez-Pastor MT, Jiang SC, Sah-Teli SK, Li L, Bentrem D, Lopaschuk G, Ben-Sahra I, O'Halloran TV, Shilatifard A, Puig S, Bergelson J, Koivunen P, Ardehali H. Iron Drives Anabolic Metabolism Through Active Histone Demethylation and mTORC1.Nat Cell Biol. 2023 Oct; 25(10):1478-1494. PMID: 37749225

Jiang, Yuhan; Li, Zhen; Sui, Dexin; Sharma, Gaurav; Wang, Tianqi; MacRenaris, Keith; Takahashi, Hideki; Merz, Kenneth; Hu, Jian. Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity. Communications Biology 2023 Jul 26; 6 (1) 778. PMID: 37495662; PMCID: PMC10372143

Rong Q, Lee Y, Tang Y, Vu T, Taboada C, Zheng W, Xia J, Czaplewski DA, Zhang HF, Sun C, Yao J. High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator. BME Front. 2022 Jul 4;2022:9891510. doi: 10.34133/2022/9891510. Epub 2022 Aug 1. PMID: 36818003; PMCID: PMC9933894.

Lee Y, Zhang HF, Sun C. Highly sensitive ultrasound detection using nanofabricated polymer micro-ring resonators. Nano Converg. 2023 Jun 20;10(1):30. doi: 10.1186/s40580-023-00378-2. PMID: 37338745; PMCID: PMC10281933.

Chen YY, Chen S, Ok K, Duncan FE, O'Halloran TV, Woodruff TK. Zinc dynamics regulate early ovarian follicle development. J Biol Chem. 2023 Jan;299(1):102731. doi: 10.1016/j.jbc.2022.102731. Epub 2022 Nov 22. PMID: 36423685; PMCID: PMC9800340.

2022

Chowdhury MAZ, Ok K, Luo Y, Liu Z, Chen S, O'Halloran TV, Kettimuthu R, Tekawade A. ROI-Finder: machine learning to guide region-of-interest scanning for X-ray fluorescence microscopy. J Synchrotron Research 2022 Nov 1;29 (Pt 6): 1495-1503. PMID: 36345757; PMCID: PMC9641565

Rong Q, Lee Y, Tang Y, Vu T, Taboada C, Zheng W, Xia J, Czaplewski DA, Zhang HF, Sun, C, Yao, J. High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator. BME Frontiers 2022 Aug. https://doi.org/10.34133/2022/9891510

Song K, Brenner B, Yeo W, Kweon J, Cai Z, Zhang Y, Lee Y, Yang X, Sun C, Zhang HF. Monolithic dual-wedge prism-based spectroscopic single-molecule localization microscopy. Nanophotonics 2022 11(8), 1527-1535. PMCID: PMC9307059 

Zee DZ, MacRenaris KW, O'Halloran TV. Quantitative imaging approaches to understanding biological processing of metal ions. Curr Opin Chem Biol. 2022 69: 102152. PMID: 35561425

Mendoza AD, Sue A, Antipova O, Vogt S, Woodruff TK, Wignall SM, O'Halloran TV. Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans. Biology of Reproduction August 2022 107(2). 406-418. PMID: 35466369

2021

Seeler JF, Sharma A, Zaluzec NJ, Bleher R, Lai B, Schultz EG, Hoffman BM, LaBonne C, Woodruff TK, O'Halloran TV. Metal ion fluxes controlling amphibian fertilization. Nature Chemistry. 2021 Jul;13(7): 683-691. PMID: 34155376; PMCID: PMC8475775

Cai Z, Zhang Y, Zhang Z, Song KH, Beckmann L, Djalilian A, Sun C, Zhang HF. Super-resolution imaging of flat-mounted whole mouse cornea. Exp Eye Res. 2021 Apr;205:108499. PMID: 33610603; PMCID: PMC8043998

Huang J, Ware HOT, Hai R, Shao G, Sun C. Conformal Geometry and Multimaterial Additive Manufacturing through Freeform Transformation of Building Layers. Advanced Materials. 2021 Mar;33(11):e2005672. PMID: 33533141; PMCID: PMC8245009