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The Quantitative Elemental Mapping for the Life Sciences (QE-Map) Resource provides technologies, expertise, and collaborative support for quantitative elemental imaging in biomedical research. QE-Map is supported by the National Institute of General Medical Sciences of the National Institutes of Health under Grant P41 GM135018.
Please acknowledge contributions of the Quantitative Elemental Mapping for the Life Sciences Resource with text similar to this when publishing:
This research was carried out in collaboration with the Resource for Quantitative Elemental Mapping for the Life Sciences under Grant P41 GM135018 from the National Institute of General Medical Sciences of the National Institutes of Health.
(41) Crawford AM, Balough JL, Chen YY, Jin Q, MacRenaris KW, Garwin S, Woodruff TK, Jacobsen C, Penner-Hahn JE, O'Halloran TV. Blank spectrum correction as a robust solution to artifacts in quantitative X-ray fluorescence mapping. Anal Chem. Accepted September 1, 2026. Manuscript ac-2026-03597c.R3.
(40) Reynolds AJ, Sue A, MacRenaris K, O'Halloran TV, Qiu TA. On-slide preparation of Caenorhabditis elegans toward quantitative, high-resolution LA-ICP-TOF mass spectrometry imaging. Anal Chem. 2026 In press. doi: 10.1021/acs.analchem.6c04271.
(39) Connon ML, He W, Jacoby R, MacLeod K, Czerniak CW, MacRenaris KW, MacLeod C, Bow D, LaMere A, Haase Z, Goldman J, Steckel M, Guillory RJ. Biocorrosion and biocompatibility of absorbable Mg-Li-Y wires for temporary cardiovascular scaffolds. Mater Today Commun. 2026. doi: 10.1016/j.mtcomm.2026.116137.
(38) Weng M, Crawford AM, Bakurov I, Vogt LI, James AK, Edwards NP, Webb SM, George SJ, George GN, Pickering IJ. Conventional and machine learning-driven corrections for beam intensity fluctuations in X-ray fluorescence imaging. Photon Sci. 2026. doi: 10.1021/photonsci.6c00034.
(37) Nikolovski M, Wang T, Sue A, MacRenaris K, Zhao H, O'Halloran TV, Hu J. Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects. J Biol Chem. 2026:113544. doi: 10.1016/j.jbc.2026.113544. PMID: 42710664.
(36) Han J, Lee Y, Feng Z, Wu Y, Wang Z, Martinez Mejia A, Bauer A, Goyal M, Lee J-M, Zhao P, Zhang HF, Sun C, Hu S. Integrated two-photon and photoacoustic microscopy for single-cell neurometabolic imaging. Nat Commun. 2026 17:8670. doi: 10.1038/s41467-026-75603-7. PMID: 42457679; PMCID: PMC13490390.
(35) Kusi-Appiah G, Schmollinger S, Mamo A, Stainbrook SC, O'Halloran TV, Strenkert D. CIA5 and its interacting metal-binding GTPase ZNG3 are degraded by the proteasome in Zn deficiency. Plant J. 2026 127(1):e71035. doi: 10.1111/tpj.71035. PMID: 42448334; PMCID: PMC13368412.
(34) Roter B, Crawford AM, O'Halloran TV, Jacobsen C. X-ray fluorescence microscopy exposure estimates using a single excitation energy. J Synchrotron Radiat. 2026 33(Pt 4):1074–1084. doi: 10.1107/S1600577526004923. PMID: 42301795; PMCID: PMC13344639.
(33) Clark MM, Kashefi K, Reguera G. Cation-driven envelope dynamics modulate outer membrane vesiculation and extracellular electron transfer in Geobacter. Nat Commun. 2026 17(1):7859. doi: 10.1038/s41467-026-74523-w. PMID: 42331822; PMCID: PMC13442872.
(32) Zhong F, Wang Z, Lee Y, Han J, Sun N, Yang S, Ji S, Zhang HF, Sun C, Hu S. Super-resolution functional photoacoustic microscopy via label-free cell tracking. Light Sci Appl. 2026 15:146. doi: 10.1038/s41377-026-02235-3. PMID: 41776160; PMCID: PMC12957476.
(31) Roter B, Crawford AM, Jin Q, Glowacki AT, Lai B, Marin FS, Maxey E, Shi X, Culotta VC, Wildeman AS, Patel NK, O'Halloran TV, Jacobsen C. Multifunctional bending magnet beamline with a capillary optic for X-ray fluorescence studies of metals in tissue sections. J Synchrotron Radiat. 2026 33(Pt 2):319–330. doi: 10.1107/S1600577526000925. PMID: 41712662; PMCID: PMC12948027.
(30) Zee DZ, Ahn SH, Crawford AM, Sinha N, Jin Q, Jacobsen C, Maxey E, Lai B, MacRenaris KW, O'Halloran TV. Substrate and standard evaluation for correlative elemental mapping of biological samples by X-ray fluorescence microscopy and laser ablation ICP-MS. J Anal At Spectrom. 2026 41(2):708–721. doi: 10.1039/d5ja00371g. PMID: 41551907; PMCID: PMC12809665.
(29) Czerniak CW, Connon ML, Wintersheimer E, Freitas E, MacRenaris KW, Schaffer JE, Griebel AJ, Zhou L, Sahoo D, Guillory II RJ. Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo. Acta Biomater. 2026 213:791–804. doi: 10.1016/j.actbio.2026.01.028. PMID: 41544917; PMCID: PMC13183297.
(28) Balough JL, O’Halloran TV, Duncan FE, Woodruff TK. Inorganic profiles of preimplantation embryos and the association of zinc with Nanog expression in the blastocyst. Reproduction 2026 171(1):xaaf014. doi: 10.1093/reprod/xaaf014. PMID: 41575144; PMCID: PMC12132419.
(27) Rangarajan AA, Ok K, Malleck MK, Ferrell MJ, O'Halloran TV, Waters CM. A cyclic di-GMP phosphodiesterase in the VSP-2 island of Vibrio cholerae is regulated by zinc and quorum sensing. mBio. 2025 16(11):e02275-25. doi: 10.1128/mbio.02275-25. PMID: 40990477; PMCID: PMC12607878.
(26) Jiang Y, Nikolovski M, Wang T, MacRenaris K, O'Halloran TV, Hu J. Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter. Chem Sci. 2025 16(38):17675–17687. doi: 10.1039/d5sc03700j. PMID: 40910126; PMCID: PMC12406047.
(25) Shapiro JA, Bhattacharyya T, Squire LA, Mallett CL, Hix JM-L, Kenney LE, Aguirre A, Shapiro EM. Go fish! Hepatic uptake of clinical hepatospecific gadolinium-based MRI contrast agents in zebrafish is similar to humans. Mol Imaging Biol. 2025 27(4):499–505. doi: 10.1007/s11307-025-02023-2. PMID: 40461717; PMCID: PMC12405032.
(24) Kim T, Hong B, Northcote R, O'Halloran TV, Lisabeth E, Neubig RR, Fiebig A, Crosson S. Reversion of a RND transporter pseudogene reveals latent stress resistance potential in Brucella ovis. PLoS Genet. 2025 21(7):e1011795. doi: 10.1371/journal.pgen.1011795. PMID: 40690529; PMCID: PMC12306736.
(23) Crawford AM, Zee DZ, Jin Q, Sue A, Sinha N, Ahn SH, O'Halloran TV, MacRenaris KW. AutoSpect: an all-in-one software solution for automated processing of LA-ICP-TOF-MS datasets. J Anal At Spectrom. 2025 40(8):2162–2178. doi: 10.1039/d5ja00145e. PMID: 40657301; PMCID: PMC12243102.
(22) Ahn SH, Halgren K, Grzesiak G, MacRenaris KW, Sue A, Xie H, Demireva E, O'Halloran TV, Petroff MG. Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology. J Immunol. 2025 214(7):1504–1516. doi: 10.1093/jimmun/vkaf054. PMID: 40267393; PMCID: PMC12311386.
(21) Hernandez-Ortiz S, Ok K, O'Halloran TV, Fiebig A, Crosson S. A co-conserved gene pair supports Caulobacter iron homeostasis during chelation stress. J Bacteriol. 2025 207(4):e00484-24. doi: 10.1128/jb.00484-24. PMID: 40084995; PMCID: PMC12004947.
(20) O'Malley A, Ray JM, Kitlas P, Ruethers T, Kapingidza AB, Cierpicki T, Lopata A, Kowal K, Chruszcz M. Comparative studies of seafood and reptile α- and β-parvalbumins. Protein Sci. 2024 33(12):e5226. doi: 10.1002/pro.5226. PMID: 39584689; PMCID: PMC11586863.
(19) He W, MacRenaris KW, Griebel A, Kwesiga MP, Freitas E, Gillette A, Schaffer J, O'Halloran TV, Guillory II RJ. Semi-quantitative elemental imaging of corrosion products from bioabsorbable Mg vascular implants in vivo. Bioact Mater. 2024 43:225–239. doi: 10.1016/j.bioactmat.2024.07.023. PMID: 39386222; PMCID: PMC11462046.
(18) Iskhakova K, Cwieka H, Meers S, Helmholz H, Davydok A, Storm M, Baltruschat IM, Galli S, Pröfrock D, Will O, Gerle M, Damm T, Sefa S, He W, MacRenaris K, Soujon M, Beckmann F, Moosmann J, O'Halloran TV, Guillory II RJ, Wieland DCF, Zeller-Plumhoff B, Willumeit-Römer R. Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stages. Bioact Mater. 2024 41:657–671. doi: 10.1016/j.bioactmat.2024.07.019. PMID: 39296873; PMCID: PMC11408010.
(17) Halim A, Mondal SK, Al-Qadi N, Kenyon E, MacRenaris K, O'Halloran TV, Medarova Z, Moore A. Monitoring of nanodrug accumulation in murine breast cancer metastases. J Vis Exp. 2024 (210):10.3791/66961. doi: 10.3791/66961. PMID: 39248512; PMCID: PMC12920022.
(16) Jiang Y, MacRenaris K, O'Halloran TV, Hu J. Determination of metal ion transport rate of human ZIP4 using stable zinc isotopes. J Biol Chem. 2024 300(9):107661. doi: 10.1016/j.jbc.2024.107661. PMID: 39128710; PMCID: PMC11630640.
(15) Pawelec KM, Hix JML, Troia A, MacRenaris KW, Kiupel M, Shapiro EM. In vivo micro-computed tomography evaluation of radiopaque, polymeric device degradation in normal and inflammatory environments. Acta Biomater. 2024 181:222–234. doi: 10.1016/j.actbio.2024.04.031. PMID: 38648912; PMCID: PMC11144086.
(14) Broda M, Jakes JE, Li L, Antipova OA, Maxey ER, Jin Q. Conservation of model degraded pine wood with selected organosilicons studied by XFM and nanoindentation. Wood Sci Technol. 2024 58(2):649–675. doi: 10.1007/s00226-024-01533-6. PMID: 39990724; PMCID: PMC11845243.
(13) Lee Y, Rong Q, Song KH, Czaplewski DA, Zhang HF, Yao J, Sun C. Theoretical and experimental study on the detection limit of the micro-ring resonator based ultrasound point detectors. Photoacoustics 2023 34:100574. doi: 10.1016/j.pacs.2023.100574. PMID: 38126078; PMCID: PMC10731384.
(12) Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A, Nejad FK, Mahmoodzadeh A, Sato T, Ramos-Alonso L, Romero AM, Martinez-Pastor MT, Jiang SC, Sah-Teli SK, Li L, Bentrem D, Lopaschuk G, Ben-Sahra I, O'Halloran TV, Shilatifard A, Puig S, Bergelson J, Koivunen P, Ardehali H. Iron drives anabolic metabolism through active histone demethylation and mTORC1. Nat Cell Biol. 2023 25(10):1478–1494. doi: 10.1038/s41556-023-01225-6. PMID: 37749225; PMCID: PMC11407783.
(11) Jiang Y; Li Z; Sui D; Sharma G; Wang T; MacRenaris K; Takahashi H; Merz K; Hu J. Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity. Commun Biol. 2023 6:778. doi: 10.1038/s42003-023-05146-w. PMID: 37495662; PMCID: PMC10372143.
(10) Lee Y, Zhang HF, Sun C. Highly sensitive ultrasound detection using nanofabricated polymer micro-ring resonators. Nano Converg. 2023 10(1):30. doi: 10.1186/s40580-023-00378-2. PMID: 37338745; PMCID: PMC10281933.
(9) Chen YY, Chen S, Ok K, Duncan FE, O'Halloran TV, Woodruff TK. Zinc dynamics regulate early ovarian follicle development. J Biol Chem. 2023 299(1):102731. doi: 10.1016/j.jbc.2022.102731. PMID: 36423685; PMCID: PMC9800340.
(8) Chowdhury MAZ, Ok K, Luo Y, Liu Z, Chen S, O'Halloran TV, Kettimuthu R, Tekawade A. ROI-Finder: machine learning to guide region-of-interest scanning for X-ray fluorescence microscopy. J Synchrotron Radiat. 2022 29(Pt 6): 1495–1503. doi: 10.1107/S1600577522008876. PMID: 36345757; PMCID: PMC9641565.
(7) Rong Q, Lee Y, Tang Y, Vu T, Taboada C, Zheng W, Xia J, Czaplewski DA, Zhang HF, Sun C, Yao J. High-frequency 3D photoacoustic computed tomography using an optical microring resonator. BME Front. 2022 2022:9891510. doi: 10.34133/2022/9891510. PMID: 36818003; PMCID: PMC9933894.
(6) Song K, Brenner B, Yeo W, Kweon J, Cai Z, Zhang Y, Lee Y, Yang X, Sun C, Zhang HF. Monolithic dual-wedge prism-based spectroscopic single-molecule localization microscopy. Nanophotonics 2022 11(8):1527–1535. doi: 10.1515/nanoph-2021-0541. PMID: 35873202; PMCID: PMC9307059.
(5) Zee DZ, MacRenaris KW, O'Halloran TV. Quantitative imaging approaches to understanding biological processing of metal ions. Curr Opin Chem Biol. 2022 69:102152. doi: 10.1016/j.cbpa.2022.102152. PMID: 35561425; PMCID: PMC9329216.
(4) Mendoza AD, Sue A, Antipova O, Vogt S, Woodruff TK, Wignall SM, O'Halloran TV. Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans. Biol Reprod. 2022 107(2):406–418. doi: 10.1093/biolre/ioac064. PMID: 35466369; PMCID: PMC9902257.
(3) Seeler JF, Sharma A, Zaluzec NJ, Bleher R, Lai B, Schultz EG, Hoffman BM, LaBonne C, Woodruff TK, O'Halloran TV. Metal ion fluxes controlling amphibian fertilization. Nat Chem. 2021 13(7): 683–691. doi: 10.1038/s41557-021-00705-2. PMID: 34155376; PMCID: PMC8475775.
(2) Cai Z, Zhang Y, Zhang Z, Song KH, Beckmann L, Djalilian A, Sun C, Zhang HF. Super-resolution imaging of flat-mounted whole mouse cornea. Exp Eye Res. 2021 205:108499. doi: 10.1016/j.exer.2021.108499. PMID: 33610603; PMCID: PMC8043998.
(1) Huang J, Ware HOT, Hai R, Shao G, Sun C. Conformal geometry and multimaterial additive manufacturing through freeform transformation of building layers. Adv Mater. 2021 33(11):e2005672. doi: 10.1002/adma.202005672. PMID: 33533141; PMCID: PMC8245009.
(4) Pawelec K, Hix J, Troia A, Sinha N, MacRenaris K, Kiupel M, O'Halloran T, Shapiro E. Material Composition and Implantation Site Affect in vivo Device Degradation Rate. Res Sq. 2026 doi: 10.21203/rs.3.rs-9360785/v1. PMID: 42094048; PMCID: PMC13142643.
(3) Schmollinger S, Kusi-Appiah G, Villegas D, Stainbrook S, O'Halloran TV, Strenkert D. Client distribution between Chlamydomonas FDX1 and FDX2 in carbon, nitrogen and sulfur assimilation. bioRxiv. 2026 doi: 10.64898/2026.01.14.699543. PMID: 41648530; PMCID: PMC12871200.
(2) Roy S, Wang Y, Aja S, Sinha N, Crawford A, MacRenaris K, Wade A, Kim K, Muchenditsi A, Torres-Hernandez L, Na C, Kralli A, Petris M, Taylor A, O'Halloran T, Tressler C, Glunde K, Lutsenko S. Non-redundant roles of copper ransporters APT7A and ATP7B in nonradrenergic signaling. bioRxiv. 2026 doi: 10.64898/2026.01.15.699802. PMID: 41648105; PMCID: PMC12871248.
(1) Schnizlein MK, Hong B, Nguyen JNT, Jones K, Rodriguez AI, Fiebig A, Campagna SR, Balunas MJ, O'Halloran TV, Crosson S. Non-redundant cardiolipin synthases shape membrane composition and support stress resilience in Bacteroides fragilis. bioRxiv. 2025 doi: 10.1101/2025.05.12.653583. PMID: 40463285; PMCID: PMC12132519.
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